Curso. XIV Escuela Latinoamericana de Neurociencias.

Organizador(es): Instituto de Investigaciones Biológicas Clemente Estable.

Lugar: Instituto de Investigaciones Biológicas Clemente Estable.

Dirección: Avda. Italia 3318. Montevideo, Uruguay.

Fecha: 16/3/2009 3/4/2009.

Invitados especiales:

Algunos de los profesores invitados:

Washington Buño (España), Catherine Carr (USA), Pablo Castillo (USA), John Hildebrand (USA), Peter Narins (USA), Marco Tulio Núñez (Chile), Alberto Pereda (USA), Juan Segura Aguilar (Chile), Philip Stoddard (USA), Lidia Szczupak (Argentina), Daniel Tomsic (Argentina),Carol Troy (USA).


Omar Macadar, Federico Dajas

Comité Organizador:

Michel Borde, Patricia Cassina, Silvia Olivera, José Luis Peña,

Giselle Prunell, Raúl Russo, Ana Silva, Cecilia Scorza.


Preliminary Program:

 1st module: March 16th to 21st: Cellular Neurophysiology and Synaptic Plasticity

 Monday March 16th


Opening lecture. Neuron, Synapsis and Circuits. Introduction to Electrophysiology. Electrophysiology of the neuron.


Experimental seminars

 Tuesday March 17th


Development of nervous system. The establishment of neuronal polarity. Progress in cortical neurogenesis. Neuronal plasticity in adult brain circuits.


Experimental seminars

 Wednesday March 18th


Patterns of cortical neurogenesis. Neurogenesis in the adult hippocampus. Does adult neurogenesis recapitulate embryogenesis?


Experimental seminars


Barro negro, teatro sobre ruedas

Round table: Animal care policies in Latin America.

Chairs: Annabel Ferreira, Cecilia Scorza, Ana Silva.

 Thursday March 19th


New tricks at old structures: novel forms of synaptic plasticity. Modulation of «spike timing dependent plasticity» (STPD). Electric synaptic transmission


Experimental seminars

Friday March 20th


Plasticity in an electric synapsis. Persistent muscarinic potentiation of the synaptic efficacy. Endocannabinoid-mediated synaptic plasticity in the CNS.   


Experimental seminars

 Saturday March 21st


Mini-symposium: Neuron and neural circuits: neural codes and plasticity.

Degeneracy in neural circuits. The control of breathing.

Neural plasticity in spinal circuits.

Neural coding at primary sensory afferences

Filter properties of neurons and circuits.

Chairs: Angel Caputi, Nicholas Mellen.


Student oral presentation (part I)

 2nd module: March 23rd to 30th: Neuron-glia interaction and nervous system pathology

 Monday March 23rd

Morning: Neuron-glia communication

An overview of CNS neurochemical interactions.

Astrocyte biochemistry and physiology.


Experimental seminars

 Tuesday March 24th

Morning: Oligodendrocytes, Schwann cells and microglia

Introducing oligodendrocytes and Schwann cells. Myelination. Microglia.


Presentation of experimental seminars by students

 Wednesday March 25th

Morning: Role of glial cells in pathology

Rol of astrocytes determining neuron survival. Demyelination. Role of microglia in neuroinflammation.


Experimental seminars

 Thursday March 26th

Morning: How to assess glial cell partipation in pathology?

In vitro and in vivo approaches. Recent molecular approaches to identify underlying pathomechanisms. How to study demyelinating pathologies: a clinical view. PET to assess glial reactivity in neurodegeneration.


Experimental seminars


Mini-Symposium: Neurodegeneration and Neuroprotection

Chairs: Patricia Cassina, Silvia Olivera, Giselle Prunell.

 Friday March 27th

Morning: Mechanisms underlying neurodegeneration

Neurodegenerative diseases: propossed pathological mechanisms. Different pathways leading to neuronal death. Oxidative stress and neurodegeneration.


Experimental seminars

 Saturday March 28th

Morning: Parkinson disease as a prototypic neurodegenerative disease

Introducing to Parkinson disease. Iron participation in Parkinson disease. Nicotinic receptor protection against Parkinson disease.


Student oral presentation (part II)

 Monday March 30th

Morning: State of the art of neuroprotective approaches

Cre/lox technology

siRNA delivery to neurons

Gene therapy against neurodegeneration

3rd module: March 30th to April 3rd: Systems underlying behaviour: Neuroethology

Monday March 30th


Round table: How to develop a scientific career.

Chairs: John Hildebrand, Omar Macadar.

Tuesday March 31st


Principles of Neural Systems. Neural networks and neural codes. Parallel evolution of neural processing patterns.


Experimental seminars

Wednesday April 1st


Sensory processing and behaviour. Sound localization. Chemoreception. Vision in invertebrates.


Experimental seminars

Thursday April 2nd


Neural bases of motor strategies. Locomotor behaviour. Electromotor systems. Communication calls.


Presentation of experimental seminars by students.


Symposium on neural bases of behavior

Chairs: Catherine Carr, Peter Narins.

 Friday April 3rd


Behavioral plasticity. Long term visual memory in arthropods. Circadian variations of an electromotor output. Sexual and seasonal plasticity of the CNS.


Meeting of the IBRO-LARC Council

Closing lecture. Closing ceremony. Party.

 Experimental seminars

 Module 1:

 – Physiology of an inhibitory synapsis in vitro

Inés Pose, Sebastián Curti. Fac. de Medicina, UdelaR

 – Electric properties of neurons in the CNS.

Raúl Russo – Cecilia Reali. IIBCE.

 – In vivo análisis of excitatory and inhibitory synapsis in the CNS of vertebrates.

Michel Borde – Alberto Pereda. Fac. de Medicina. UdelaR

 – Synaptic plasticity in vitro.

Pablo Castillo. IIBCE.

 – Neuronal designs for the elaboration of rhythmic efferences in the CNS.

Nicholas Mellen, Jean-René Cazalets. Fac. de Medicina, UdelaR

 – Astrocyte-mediated neurotoxicity to motorneurons.

Patricia Cassina y Hugo Peluffo. Facultad de Medicina, UdelaR

 – Astrocyte response to injury and its effects on CNS neurons survival.

Silvia Olivera y Giselle Prunell, IIBCE

 Module 2:

 – Myelination in in vitro models.

Alejandra Kun y José Sotelo, IIBCE

 – Evaluation of brain performance by in vivo microdyalisis and behavior.

Cecilia Scorza y Juan Andrés Abin, IIBCE

 – Hypoxic-ischemic models and evaluation of brain damage.

Fernanda Blasina y Felicia Rivera, IIBCE

 – Neural bases of visual and auditory perception.

José Luis Peña, Leonel Gómez. Facultad de Ciencias, UdelaR.

 – Neural mechanisms of the novelty response.

Angel Caputi, IIBCE.

 – Modulation of reproduction and aggression.

Ana Silva, Philip Stoddard, Kent Dunlap, IIBCE.

 -Neural bases of maternal behavior

Annabel Ferreira, Facultad de Ciencias, UdelaR

 -Role of the Pontine Reticular Formation in the generation of REM sleep.

Pablo Torterolo, Patricia Lagos. Facultad de Medicina, UdelaR.

Fuente y más información: Zona Eventos.